Everyone's favorite lazy, lasagna loving, Monday hating orange tabby leaves his exciting star of a popular comic strip world for the real one. But as the novelty wears thin, Garfield begins looking for a way back before his strip is permanently cancelled.

Garfield's 29-year winning streak in the annual Fun Fest talent competition is threatened by a dashing new entrant, Ramone, who possesses great charm. Concerned about losing his touch, Garfield goes on a quest to seek Freddy Frog's mythical pond, where it is said that anyone who drinks from it is certain to be funny.

Nothing in the world can make Garfield get involved in anything besides eating, until the muscular super cat Garzooka comes crashing into Cartoon World from the Comic Book universe with terrifying news. Garfield summons up the willpower to join his superhero Garzooka in a fight to save their worlds.