Ketika Cinta Bertasbih berfokus pada perjalanan tokoh Azzam (M. Cholidi Asadil Alam), seorang mahasiswa Indonesia yang menuntut ilmu di Universitas Al Azhar Kairo-Mesir. Kuliahnya tertunda selama 9 tahun setelah ayahnya meninggal dunia, sehingga demi menghidupi dirinya dan keluarganya di Solo Azzam berdagang bakso dan tempe di Kairo-Mesir.
Mas Gagah was changed. After went to Ternate for his assignment suddenly he changed drastically. His sister, Gita Ayu can't accept this. She thought Mas Gagah is a new person who totally different from the previous one.
Traumatized by the conflict situation that occurred in Palestine made Hayya not want to be sent home, and fled again so that he could live in Indonesia. While on the run, Hayya meets Lia, a beautiful and kind woman who thinks Hayya is her son. Hayya was invited by Lia to stay at his house and meet with Faisal. Faisal who was initially confused by Hayya's presence, finally considered Hayya a savior for his domestic life. Elsewhere, Rahmat, Adhin, and Ricis continue to look for Hayya. Then one by one the veil of the Faisal family opened, until at its peak, a tragedy befell Hayya, making the situation complex and tense.
Haunted by the sins in his past, a journalist decides to become a humanitarian volunteer in the Palestinian border refugee camp. In that area, he meets Hayya, an innocent orphaned girl who is a victim of the conflict in Palestine.
With background experience for entrepreneurship in Egypt, Azzam was not discouraged even to start business on its own. But how to get married, it is always alluded to by his mother. Women who his admired, Anna Althafunnisa has been proposed by his best friend. Whereas with Eliana whom he not love, it create much confusion. Azzam also trying to find his moorings, although quite a lot of the barriers that they face, which then makes it almost hopeless.
Siti Zahrana’s academical success makes her parents worried. Zahrana hasn’t married by her early thirties. There have been many men who solicited her, but she has refused them all politely. Zahrana’s conflicting issues spring up: to follow her parents’ wish or to pursue her own dreams. Actually she has relented once. She turns down a teaching post at Gadjah Mada University. The reason, her parents who live in Semarang don’t want her to be away. So Zahrana teaches at a Semarang university and stays with them. Then she also passes up a doctoral scholarship opportunity from China.