The Oxbow Cure is a winter tale of Lena, a middle-aged woman who has recently been diagnosed with a life-altering disease. In an attempt to come to terms with her transforming body, she leaves her home in the city for a new life in remote northern Ontario. While exploring the natural world outside her cottage, she begins to create an interior routine. A frozen lake, mere steps from her front door, is a source of both fear and fascination.

Returning to the same medical school where they were test subjects years before, two twisted serial killers use brutal sex acts to kill off a group of med students.