Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.

The nicest guy in the Midwest moves his family into a tough neighborhood in Los Angeles where not everyone appreciates his extreme neighborliness. That includes their new next-door neighbor Calvin.

Kat is a woman who struggles every day against society and her mother to prove that she can still live a happy and fulfilling life despite still being single at 39. Which is why she recently spent her entire savings to open a cat café in Louisville, Kentucky.

Georgie and Mandy raise their young family in Texas while navigating the challenges of adulthood, parenting, and marriage.