Three brother bears awkwardly attempt to find their place in civilized society, whether they're looking for food, trying to make human friends, or scheming to become famous on the internet. Grizzly, Panda and Ice Bear stack atop one another when they leave their cave and explore the hipster environs of the San Francisco Bay Area, and it's clear the siblings have a lot to learn about a technologically driven world. By their side on many adventures are best friend Chloe (the only human character in the cast), fame-obsessed panda Nom Nom, and Charlie, aka Bigfoot.
The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."