Sato's life – or what's left of it – is a paranoid mess of conspiracy theories and social anxieties. He's terrified of the outside world; his apartment is overflowing with the remnants of cheap take-out food; and his retinas have been permanently scarred by a steady diet of internet porn. But maybe it's not all his fault. After all, the nefarious N.H.K. is out there, and they’re determined to turn society's fringe-dwellers into a brainwashed lot of jobless, hopeless, futureless recluses. Enter Misaki – a mysterious girl-next-door type who is Sato's last chance to beat-down his inner demons and venture out into the light of day. She's ready to help him overcome his crippling phobias, but Sato would rather cower in his existential foxhole and pretend to work on the demo for his virtual sex game. He’s afraid to face the world. She's strangely desperate to fix a total stranger. Maybe together they can be normal.

Iwaki Tomonori is a schoolboy who happens to have a crush on his teacher, but learns she has become engaged. Brokenhearted, he soon meets a girl named Rizel, a biochemically engineered human, who he learns the Japanese government has married him to against his will.

A terminally ill girl named Himari Takakura is miraculously saved from death by a strange spirit who resides in a penguin-shaped hat. However, in exchange for extending her life, the spirit tasks Himari's brothers, Kanba and Shōma, to seek out an elusive item known as the Penguin Drum with assistance from a trio of strange penguins.

Night Wizard. A term given to those whose mission is to protect the world from impending darkness. Renji Hiiragi is one such Night Wizard, who is constantly called on missions, even though all he wants is to be able to go to school and graduate.

One day, Naho Takamiya receives a letter written to herself from ten years in the future. As Naho reads on, the letter recites the exact events of the day, including the transfer of a new student into her class named Kakeru Naruse. The Naho from ten years later repeatedly states that she has many regrets, and she wants to fix these by making sure the Naho from the past can make the right decisions—especially regarding Kakeru. What's more shocking is that she discovers that ten years later, Kakeru will no longer be with them. Future Naho asks her to watch over him closely.