The series follows the lives and loves of three 30-something professionals in modern day Athens. Elli (Faidra Douka) is a junior executive in a record company, having to deal with a highly demanding bitch-of-a-boss. Following the end of a serious relationship, Elli is worried about never having a chance to marry or have kids. Her search for new partners mostly results in the entry of weirdos in her life. Mitsaki (Mirto Alikaki) is a radio producer with a love-hate-relationship with her own boss. A life-long party girl with a tendency towards short-lived relationships and an aversion to taking any short of responsibility, Mitsaki has to come to grips with the idea of growing up. Billy (Giorgos Pyrpassopoulos) is a reporter with a rather unsteady love-life. He is a homosexual, but tends to be turned-off by the quirks of his various partners and has yet to fully commit to a relationship.

Coupling is a 2007 Greek remake of the British television sitcom of the same title which aired on ANT1. The show was directed by Stephanos Kodomari, and written by Tina Kampitsi. The series started being broadcast on November 15 2007 at 23:00. The series was then dropped by ANT1 in February 2008 due to low ratings.