Kat receives a weekend at a couples retreat as a gift from her mother, even though she and her boyfriend had broken up six month prior. Kat's friend Samantha proposes that they pretend to be a couple and go there anyway.
Josh Futturman, a janitor by day/world-ranked gamer by night, is tasked with preventing the extinction of humanity after mysterious visitors from the future proclaim him the key to defeating the imminent super-race invasion.
Zack and Cody Martin are aboard the SS Tipton, a luxury passenger cruise liner owned by London's father. The ship cruises the world with tourists and students who attend classes at Seven Seas High, the one high school that London's dad thinks will make his daughter a better student. While out at sea, Zack and Cody still have their compass pointed towards mischief, and London learns to live a "fabu-less" lifestyle, including sharing a small room with Bailey, a country girl from Kansas.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.