London, 1761. St. Mary's of Bethlehem, a sinister madhouse, is visited by wealthy people who enjoy watching the patients confined there as if they were caged animals. Nell Bowen, one of the visitors, is horrified by the deplorable living conditions of the unfortunate inhabitants of this godforsaken place, better known as Bedlam.
Edinburgh, 1831. Among those who undertake the illegal trade of grave robbery is Gray, ostensibly a cab driver. Formerly a medical student convicted of grave robbery, Gray holds a grudge against Dr. MacFarlane who had escaped detection and punishment.