After killing a prison guard, convict Robert Stroud faces life imprisonment in solitary confinement. Driven nearly mad by loneliness and despair, Stroud's life gains new meaning when he happens upon a helpless baby sparrow in the exercise yard and nurses it back to health. Despite having only a third grade education, Stroud goes on to become a renowned ornithologist and achieves a greater sense of freedom and purpose behind bars than most people find in the outside world.

Carl Panzram is sent to Leavenworth Prison for burglary. While there, he is brutally beaten by a guard. Neophyte guard Henry Lesser feels sympathy for Panzram, befriends him, and gets him to write his life story. Lesser learns that Panzram's past is much more violent than he thought, but also that he's capable of being a much better person than the rest of the prison staff believes - or so Lesser thinks.