Danni Lowinski is a hairdresser in need of money who decides to become a lawyer.

A successful vascular surgeon is suddenly confronted with a blood phobia, making it impossible for him to exercise his job in the hospital. He moves from the capital to the countryside to work as the GP of a village where he only knows his aunt. His predecessor was well liked, so his new community is less than welcoming. The empathic capabilities of the doctor leaves much to be desired, making it even harder for him to win his place in the close-knit community.

To Hester, Sabine and Rachel, three sisters of wealthy parents, everything comes naturally and they never had a care in the world. That all changes when they get involved in a car accident.

Flikken Rotterdam takes place in Rotterdam, and is after Flikken Maastricht the second Dutch spin-off of the Flemish show Flikken.

Former Amsterdam police detective Floris Wolfs has been transferred to the police department of the south-Dutch country town Maastricht. His metropolitan experience nicely complements the local expertise of his new country colleagues, who know the folks. Slowly he fits in, while solving countless crimes together with his female partner Eva van Dongen.