Publisher Will Atenton quits a lucrative job in New York to relocate his wife, Libby, and their daughters to a quaint town in New England. However, as they settle into their home the Atentons discover that a woman and her children were murdered there, and the surviving husband is the town's prime suspect. With help from a neighbor who was close to the murdered family, Will pieces together a horrifying chain of events.
When Linda Michaels (Penny Eizenga) wakes to find her teenaged son, Kevin (Jamie Johnston), has left home in the middle of the night, she begins the all-too-familiar search for him in the gritty downtown streets of the city. Kevin refuses treatment for schizophrenia, causing him to become more and more erratic and paranoid.
After saving the life of the President, two secret service agents - Myka Bering and Pete Lattimer - find themselves assigned to the top secret Warehouse 13. The Warehouse is a massive, top secret facility that houses dangerous and fantastical objects. Together, Pete and Myka along with fellow agents Claudia, Steve Jinks and Warehouse caretaker Artie, must recover artifacts from around the globe before they can cause catastrophic damage.