Former 1960s flower children Steven and Elyse Keaton raise their conservative son Alex, daughters Mallory and Jennifer, and later, youngest child Andrew.

Fatherhood has taken on a whole new meaning for Jason Seaver, who has assumed the chores of cooking, cleaning and minding the kids so that his wife, Maggie, can pursue a career in journalism after spending 15 years as a housewife.

Garry Shandling stars as himself, a neurotic, sardonic stand-up comedian who just happens to be aware he is a sitcom character. Garry spends just as much time interacting with the studio audience as he does the regular cast members, performing monologues and show-closing summations of the episode's events. However, everyone knows they're on TV, not just Garry; and the audience (itself a character) is often involved in the storyline.