A Philadelphia couple are in mourning after an unspeakable tragedy creates a rift in their marriage and opens the door for a mysterious force to enter their home.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Su Cheng is a college senior who is a diehard fan of Yen Chu Fei. In order to get close to her idol, she starts working as a personal assistant for a celebrity and eventually signs with a management company headed by Duan Cheng Xuan. Her life decisions don't seem to be inspired inspired by the smartest reasons but this is also a story of self-discovery as the budding actress learns to develop a passion for the stage.

Mary Ann returns to present-day San Francisco and is reunited with her daughter and ex-husband, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal, her chosen family and a new generation of queer young residents living at 28 Barbary Lane.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Eight interconnected stories told over 33 years explore how our planet’s changing climate will affect family, work, faith—and survival.

Thomas Magnum, a decorated former Navy SEAL, returns home from Afghanistan and applies his military skills to become a private investigator in Hawaii taking jobs no one else will—with the help of fellow vets T.C. Calvin and Rick Wright, and former MI:6 agent, Juliet Higgins.