Walter White, a New Mexico chemistry teacher, is diagnosed with Stage III cancer and given a prognosis of only two years left to live. He becomes filled with a sense of fearlessness and an unrelenting desire to secure his family's financial future at any cost as he enters the dangerous world of drugs and crime.

Harmon "Harm" Rabb Jr. is a former pilot turned lawyer working for the military's JAG (Judge Advocate General) division, the elite legal wing of officers that prosecutes and defends those accused of military-related crimes. He works closely with Lt. Col. Sarah Mackenzie, and together they do what needs to be done to find the truth.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.