Follow a dysfunctional team of MI5 agents—and their obnoxious boss, the notorious Jackson Lamb—as they navigate the espionage world's smoke and mirrors to defend England from sinister forces.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Ten thousand years before the ascension of Paul Atreides, sisters Valya and Tula Harkonnen establish the fabled sect and female order that would become known as the Bene Gesserit to control the future of humankind.