Two sisters with Asperger's syndrome struggle to find their place in society. One is determined to face the world just as she is, and the other is obsessed with becoming someone else to fit in.
An ex-Navy seal, his girlfriend and their friends head out on a road trip to New Orleans. The group decides to stop at a roadside convenience store owned by Chopper, who tells them the tale of Lockjaw, a fabled god-like creature who is half-man, half-alligator.
An archeology professor unearths a dangerous artifact, unwittingly releasing a creature that is able to kill with the power of its bone-splitting scream.