A reporter stumbles upon the journal of a murderer with plans to butcher specific girls, and he begins to investigates on his own, and finding that every trail leads to a 9-year-old orphan living in a group home.

Everyone's favorite lazy, lasagna loving, Monday hating orange tabby leaves his exciting star of a popular comic strip world for the real one. But as the novelty wears thin, Garfield begins looking for a way back before his strip is permanently cancelled.