On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker -- who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.
An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.