A comedy-drama following a chaste young woman who is accidentally impregnated via artificial insemination as she struggles to inform her devoutly religious family and make the right choices concerning the child. Based on the telenovela "Juana la virgen."

The Casagrandes tells the story of Ronnie Anne, an independent, adventurous, 11-year-old who explores city life with her big, loving, multi-generational Mexican-American family.

After reluctantly returning to her tourist-trap hometown of Roswell, New Mexico, the daughter of undocumented immigrants discovers a shocking truth about her teenage crush who is now a police officer—he’s an alien who has kept his unearthly abilities hidden his entire life. She protects his secret as the two reconnect and begin to investigate his origins, but when a violent attack and long-standing government cover-up point to a greater alien presence on Earth, the politics of fear and hatred threaten to expose him and destroy their deepening romance.