New veterinary school graduate Dr. Andrew McDonald encounters many challanges on his first day as an intern at a rural but busy veterinary hospital. Along with the beasts, there is legendary chief veterinarian Dr. Cyrus Gachet, the cynical senior surgeon Dr. Kyle Southern, and a pretty young vet Dr. Emma Matthews. There is a ferret, a wounded cat, a St. Bernard dog, two horses, a deer and a fire to endure.

Reason Boles is on a mission to stop loggers from destroying his family's ancestral land. In a chance encounter, he meets Addy and her 7-year-old daughter Bell, who are fleeing their past in the hopes of starting a new life. Together, Reason and Addy are given the chance to transcend the violence in their lives, or be destroyed by it.

In 1960s Wyoming, two men develop a strong emotional and sexual relationship that endures as a lifelong connection complicating their lives as they get married and start families of their own.

Tony is framed by Claremont for a murder he didn't commit. He is sent to prison but Claremont promises him freedom if he can find Allie in the prison and bring her out. Allie and Tony soon join forces and the actual escape from the prison is a small part of what they will go through together.

Estranged from his father, college student Jake is lured home to New York for Christmas with the promise of receiving a classic Porsche as a gift. When the bullying football team dumps him in the desert in a Santa suit, Jake is left without identification or money to help him make the journey. Meanwhile, his girlfriend, Allie, does not know where he is, and accepts a cross-country ride from Jake's rival, Eddie.

As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.