A drama about a multi-generational family of cops dedicated to New York City law enforcement. Frank Reagan is the New York Police Commissioner and heads both the police force and the Reagan brood. He runs his department as diplomatically as he runs his family, even when dealing with the politics that plagued his unapologetically bold father, Henry, during his stint as Chief.

Regina Haywood is the newly promoted deputy inspector of East New York, a working-class neighborhood at the edge of Brooklyn. She leads a diverse group of officers and detectives, some of whom are reluctant to deploy her creative methods of serving and protecting in the midst of social upheaval and the early seeds of gentrification.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.