After saving the life of the President, two secret service agents - Myka Bering and Pete Lattimer - find themselves assigned to the top secret Warehouse 13. The Warehouse is a massive, top secret facility that houses dangerous and fantastical objects. Together, Pete and Myka along with fellow agents Claudia, Steve Jinks and Warehouse caretaker Artie, must recover artifacts from around the globe before they can cause catastrophic damage.

The gorgeous and charismatic Bo is a supernatural being called a succubus who feeds on the energy of humans, sometimes with fatal results. Refusing to embrace her supernatural clan and its rigid hierarchy, Bo is a renegade who takes up the fight for the underdog while searching for the truth about her own mysterious origins.