A man who escorts wealthy widows in New York's Upper East Side takes a young aspiring playwright under his wing.

Freshman high-school student Melinda has refused to speak ever since she called the cops on a popular summer party. With her old friends snubbing her for being a rat, and her parents too busy to notice her troubles, she folds into herself, trying to hide her secret: that star senior Andy raped her at the party. But Melinda does manage to find solace in her art class headed by Mr. Freeman.

Columbus, Tallahassee, Wichita, and Little Rock move to the American heartland as they face off against evolved zombies, fellow survivors, and the growing pains of the snarky makeshift family.

Twenty years ago, Arlen Faber wrote a book about spirituality that became wildly popular. These days, he's a curmudgeonly recluse who only enjoys the company of his chiropractor, Elizabeth. As Elizabeth's warmth starts to melt Arlen's cold heart, he comes to realize what love really means.

In the mid-1960s, wealthy debutant Edie Sedgwick meets artist Andy Warhol. She joins Warhol's famous Factory and becomes his muse. Although she seems to have it all, Edie cannot have the love she craves from Andy, and she has an affair with a charismatic musician, who pushes her to seek independence from the artist and the milieu.

Six strangers find themselves in circumstances beyond their control, and must use their wits to survive.