Ray Tango and Gabriel Cash are two successful narcotics detectives who can't stand each other. Crime lord Yves Perret, furious at the loss of income they have caused him, plots an elaborate revenge against them.
Due to an experimental vaccine, Dr. Robert Neville is the only human survivor of an apocalyptic war waged with biological weapons. Besides him, only a few hundred deformed, nocturnal people remain - sensitive to light, and homicidally psychotic.
An over-the-hill heavyweight boxing champion who suffers from the ravages of years of head trauma is exploited by his manager, despite the efforts of a compassionate young woman who tries to help him recover his self-respect.
