A 16-year-old international assassin yearning for a "normal" adolescence fakes her own death and enrolls as a senior in a suburban high school. She quickly learns that being popular can be more painful than getting water-boarded.
Street dancer, Thomas Uncles is from the wrong side of the tracks, but his bond with the beautiful Megan White might help the duo realize their dreams as they enter in the mother of all dance battles.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
Deputy Police Chief Brenda Leigh Johnson transfers from Atlanta to LA to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Johnson's quirky personality and hard-nosed approach often rubs her colleagues the wrong way, but her reputation as one of the world's best interrogator eventually wins over even her toughest critics.