Dr. Henry Jekyll believes that there are two distinct sides to men - a good and an evil side. He believes that by separating the two, man can become liberated. He succeeds in his experiments with chemicals to accomplish this and transforms into Hyde to commit horrendous crimes. When he discontinues use of the drug, it is already too late.
Based partially on the story of Bonnie and Clyde, Eddie Taylor is an ex-convict who cannot get a break after being released from prison. When he is framed for murder, Taylor is forced to flee with his wife Joan Graham and baby. While escaping prison after being sentenced to death, Taylor becomes a real murderer, condemning himself and Joan to a life of crime and death on the road.