The story of Claire Randall, a married combat nurse from 1945 who is mysteriously swept back in time to 1743, where she is immediately thrown into an unknown world where her life is threatened. When she is forced to marry Jamie, a chivalrous and romantic young Scottish warrior, a passionate affair is ignited that tears Claire's heart between two vastly different men in two irreconcilable lives.

Set against the backdrop of the greatest clandestine race against time in the history of science with the mission to build the world's first atomic bomb in Los Alamos, New Mexico. Flawed scientists and their families attempt to co-exist in a world where secrets and lies infiltrate every aspect of their lives.