The brilliant biochemist Helen Reynolds ingests the brain fluid of a serial killer as part of a self-experiment. She hopes to discover the secret behind the killer's ability to psychically control his victims.

'Til Death will take fans on one wild ride until screeching to its final destination. Celess gets a glimpse into Si Si's world where Si Si connects with old friends and adopts new frenemies in a desperate effort to confront her past before colliding with it head on. Who will survive the collision is the question that will loom in fans' heads at every gut-wrenching twist and head-spinning turn.

A case involving drug lords and murder in South Florida takes a personal turn for undercover detectives Sonny Crockett and Ricardo Tubbs. Unorthodox Crockett gets involved romantically with the Chinese-Cuban wife of a trafficker of arms and drugs, while Tubbs deals with an assault on those he loves.