Donna DeGregorio was born and raised in Philadelphia, Pennsylvania, United States to Iliana Orselli and Donald DeGregorio. The youngest of 4 girls. Donna is of Italian American descent. She is an Actress, Model, Host and has performed in numerous stage plays. Donna has appeared on HBO, Comedy Central, MTV, USA, TruTv and Bravo. She studied acting at Playhouse West under the instruction of Tony Savant. She previously studied improvisation and musical theatre at the Walnut Street Theatre in PA. Donna is a certified Personal Trainer/Health Coach which landed her a recurring role as Sparkle on Broad City-Comedy Central as a Personal Trainer. She has appeared on Season 2, 3 and 4.

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