Three sisters - Georgia, Eve, and Maddy - do what they do best with life, love, and lunacy on the telephone lines that bind - when their curmudgeonly father, Lou, is admitted to a Los Angeles Hospital. After years of wild living, intermittent affection, and constant phoning, he is finally threatening to die.
A stranger's call informs Roberta that her estranged brother Frank has died in a small town under bizarre circumstances. Ben, his best friend from college, also gets the call. Arriving just in time for his funeral, it becomes quickly obvious to them that the little slice of small-town America in which they find themselves is like an episode of The Twilight Zone featuring Frank's eccentric friends, his amazing secrets and his stunning final request. Both Ben and Roberta are shocked to discover that Frank not only had a child, but that he has left them responsible for his son's care.
Patsy McCartle is a widow with two sons trying to gather all the money she has to pay for her car, bills, and her son's medication, all of which she can barely afford. She turns to dealing drugs and becomes addicted to crystal meth.
When her daughter Sara unexpectedly passes away, Natalie retreats to the summer home where she and Sara used to visit. Time with her best friends and some of Sara's friends help her deal with her loss.
After suffering a personal tragedy, and desperate for justice, Jacob Kanon, a veteran New York City police detective, embarks on the search for a twisted killer who is leaving a bloody trail of elaborate murders across Europe.
Alex Cross is a brilliant but flawed homicide detective and full of contradictions. A doting father and family man, Cross is single-minded to the point of obsession when he hunts killers. He is desperate for love, but his wife’s murder has left him too damaged to receive it.
Jane Smith is a brilliant, tough, and darkly funny defense attorney in the Hamptons. Up to this point, Jane has only cared about winning; however, her world is completely turned upside down when, on the eve of the biggest case of her career, she is diagnosed with a terminal brain tumor.