Determined to ensure Superman's ultimate sacrifice was not in vain, Bruce Wayne aligns forces with Diana Prince with plans to recruit a team of metahumans to protect the world from an approaching threat of catastrophic proportions.

An endless army of shadow demons bent on the destruction of all reality swarms over our world and all parallel Earths! The only thing opposing them is the mightiest team of metahumans ever assembled. But not even the combined power of Superman, Batman, Wonder Woman, Green Lantern and all their fellow superheroes can slow down the onslaught of this invincible horde. What mysterious force is driving them? And how do the long-buried secrets of the Monitor and Supergirl threaten to crush our last defense?

Now fully revealed as the ultimate threat to existence, the Anti-Monitor wages an unrelenting attack on the surviving Earths that struggle for survival in a pocket universe. One by one, these worlds and all their inhabitants are vaporized! On the planets that remain, even time itself is shattered, and heroes from the past join the Justice League and their rag-tag allies against the epitome of evil. But as they make their last stand, will the sacrifice of the superheroes be enough to save us all?

The Justice League faces a powerful new threat — the Fatal Five! Superman, Batman and Wonder Woman seek answers as the time-traveling trio of Mano, Persuader and Tharok terrorize Metropolis in search of budding Green Lantern, Jessica Cruz. With her unwilling help, they aim to free remaining Fatal Five members Emerald Empress and Validus to carry out their sinister plan. But the Justice League has also discovered an ally from another time in the peculiar Star Boy — brimming with volatile power, could he be the key to thwarting the Fatal Five? An epic battle against ultimate evil awaits!