Dr Lucien Blake left Ballarat as a young man. But now he finds himself returning to take over not only his dead father's medical practice, but also his on-call role as the town's police surgeon, only to find change is afoot, nothing is sacred, and no one is safe.

City Homicide follows a group of detectives in the Homicide department of Melbourne's Metropolitan Police Headquarters.

Medical drama focusing on the working and personal lives of the doctors and nurses working on the front line of a busy inner city Emergency Department at All Saints Hospital.