Prema Geema Jaane Do is a soft romantic comedy. The movie is about the protagonist setting up a journey to a new place and meeting new people. Why he hates love and what is in his past forms the main crux of the story.

Six people are at various stages of life: Sachin proposes to Saanvi, but she is skeptical because her elder sister is unmarried. Shashi sees the love of his life when he is at the Railway station to pick his mother up. Sathya, up to no good at a medical camp, falls in love with a girl he meets there.

When he was just a baby, Appu got separated from his family following a gruesome road accident. He was then adopted and raised by a kind villager named Ranganna, who became a father figure to Appu. Years later, following Ranganna`s death, Appu sets out on a journey to find his real parents, even as he tries to reconcile with the loss of his foster father.