Nai Hoi Tamin is about the difficult life of the people of the East of Thailand – in a time when drought and poverty forced them to bring their buffalos for sale around the center of Thailand. There was a strong leader, “Nai Hoi Tamin”, who led the big caravans for the long and sometimes dangerous trip. Along the way, they had to deal with many kind of hardships, such as robbers and thieves, illness, and the difficulty of traveling.

Ongtee/Tawan inherited a terrible curse when he was assaulted by a Tiger with the Spirit of a Saming, when he remain a foolish boy. He enters personal contact with his childhood friend and love Muayjerng/Pimsai. Surrounding them is wicked men who will perform anything to come to be what they desire. Tawan presently has to confront the daunting task of defending the battered woman he worships and curing himself of a monstrous curse. A dreadful curse that no man can easily cure. He constitutes not only a danger to others, but to the people he loves. Will Tawan overcome the obstacles and be with his love again?

Songkran is a real estate mogul a total womanizer with a son named Pe. But he didn’t start out like this, though. Pe’s mother left him when he was young to be with another man. Kran was heartbroken and began treating women like toys and gained the nickname ‘Invincible Casanova’ along with his best friend Sia Ou who runs a modelling agency.

Mike is half-Thai half-Hong Konger. Fang and Mike dated before and their fathers were close friends. After they broke up, Fang returned to Thailand and become a teacher and kindergarten owner. After Mike's father is killed, he also returned to Thailand to investigate the case. Police officer Tom is assigned to handle the case but Mike does not trust Thai police, so he does his own investigation. Both Mike and Tom are fighting for Fang.

Jao Sua Leng, the 2nd generation dragon heir to Mongkorn Waree, the owner of a shipping and transport company who famously was given the name Mongkorn Waree of the Sea. He arranged for a celebration to introduce his project that cost more than a billion without listening to the objection from his left hand, Lao Ngow, a close friend of his dad who helped build his family's fortune. Lao Ngow was jealous and wanted to get rid of Jao Sua Leng by sending Duangkae to be Jao Sua's lover so she can spy for him. During the banquet a group of hitmen invaded and shot many people there dead including Jao Sua's wife and his kid (s). Jao Sua narrowly escaped death with the help of Praosaeng, a waitress there. She took care of him and the two felt in love resulting in her pregnancy.

Tiaoleng, a successful businessman in Phuket, was murdered. His grandson Chalumpol must find out the truth, meanwhile he starts to have feelings for Nampueng, who he met before but now she comes with a new status, his young step grandma.

After a one-night stand with Pokpong, a male dancer Lalin meets at her friend's bachelorette party, Lalin decides to hire him. The job is simple; Pokpong is to marry Lalin for a few months so she can prove to her family that she deserves to be the heiress of her father's company. Things start to change when Lalin discovers there is more to Pokpong, than just a one-night stand.

The parents of Nueng and Song got divorced when they were little. The mother took the oldest twin, Nueng, while the father took the younger twin, Song. The twin had different personalities because of how they were raised, for Nueng, she had a poor lifestyle and was raised by her mother and stepfather. She is confident in herself, spoiled, and loves to have fun, especially with many men. As for Song, ever since her father died, she was raised by her aunt and uncle who gave her a good education and a loving home. Song is a gentle, innocent, and bright woman. When Nueng got in trouble with At, who's a police officer, he began to suspect her for many things. He got more suspicious when he saw that his brother's fiancee, was the same woman he had met earlier, but what he didn't know was that it wasn't Nueng, it was Song... more confusion occurs when Nueng started to create more problems, but Song was the one being suspected and blamed for it by At.

Singh used to work for the baddies. After he retired from the group, he returned to his hometown only to find out that his family members were killed. He later joined a thief gang lead by Dao in order to fight the baddies. They both had a bad past with the bad guys lead by a man who is actually his brother-in-law.

Pin Anong is the daughter of Ounreuan, the housemaid of Khun Nai Kongsook at the Phaisaan's Farm and Resort. Ounreuan was an orphan who became grateful of Khun Nai's family for raising her and providing her with a shelter and education. Ounreuan taught her daughter to be grateful of Khun Nai also because Khun Nai supported Pin's education until she received her bachelor degree. At the farm Khun Nai was known as the evil witch who mistreated Ounreuan and Pin Anong and exploited the workers at the farm by refusing to pay them wages.

Tai decided to quit being a promising police officer because Terd the honest former police officer of the village, suddenly died from being poisoned and being chased until the car fell off the cliff after attending the funeral of the mother of Nada, a beautiful nurse in the village. But because of his strength, Terd did not die. Terd was rushed to the hospital and it was at the same time that Tai went to see his father. Before his last moment, Terd gave Tai a sacred amulet before a mysterious gunman shot him down and shot his father again. Tai miraculously survived.