It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.

Skeptical forensic psychologist Kristen Bouchard joins priest-in-training David Acosta and technology expert Ben Shakir as they investigate supposed miracles, demonic possessions, and other extraordinary occurrences to assess for a scientific explanation or if something truly supernatural is at work.

The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.