Sarah Silverman plays a character named Sarah Silverman, whose absurd daily life unfolds in scripted scenes and songs. With her sister and her gay neighbors by her side, Sarah always manages to fall into unique, unsettling and downright weird predicaments.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

Drew is an assistant director of personnel in a Cleveland department store and he has been stuck there for ten years. Other than fighting with co-worker Mimi, his hobbies include drinking beer and not being able to get dates. To make a few extra bucks he has a micro-brewery going in his garage with his buddies.