After a wild night, wealthy Michael Reston's adulterous wife Charleen comes home with her ripe young body barely concealed by a dress in rags; murder results. Top New York defense lawyer J.G. Blane, whose own marriage exists in name only, arrives in Desert View, Nevada to find the townsfolk and politically powerful Sheriff Hoak distinctly hostile to the Restons. In due course, Blane discovers he's been "taken for a ride," and that quiet desert communities can be deadly.
During the Klondike Gold Rush, a misanthropic cattle driver and his talkative elderly partner run afoul of the law in Alaska and are forced to work for a saloon owner to take her supplies into a newly booming but lawless Candian town.
In a changing world where television has become the main source of information, Adam Caulfield, a young sports journalist, witnesses how his uncle, Frank Skeffington, a veteran and honest politician, mayor of a New England town, tries to be reelected while bankers and captains of industry conspire in the shadows to place a weak and manageable candidate in the city hall.
A woman who believes she has been chosen by God to heal people is taken in by a greedy promoter and his shrewish wife to make the rounds of the rural South.
Schoolteacher Bertram Cates is arrested for teaching his students Darwin's theory of evolution. The case receives national attention and one of the newspaper reporters, E.K. Hornbeck, arranges to bring in renowned defense attorney and atheist Henry Drummond to defend Cates. The prosecutor, Matthew Brady is a former presidential candidate, famous evangelist, and old adversary of Drummond.
A Union Cavalry outfit is sent behind confederate lines in strength to destroy a rail supply center. Along with them is sent a doctor who causes instant antipathy between him and the commander. The secret plan for the mission is overheard by a southern belle who must be taken along to assure her silence.