Zhu Kaishan, a man from Shandong joins settlers in northeast China during the mid-19th century. Amidst turmoil, his family embarks on a journey to reunite, facing numerous challenges as they navigate survival in an unstable era.
Professor Ren Xinzheng resigns to start a mentoring class for traditional Chinese medicine, hoping to train true successors. His students—Sun Toutou, his son Ren Tianzhen, lawyer-turned-student Yang Xiaohong, pediatrician Peng Shiyan, and aspiring doctor Zhao Liquan—struggle to get along, but must work through their differences to preserve the legacy of Chinese medicine.