Satrio, nicknamed Yoyo, is a 23-year-old guy with a limited intelligence equivalent to an eight-year-old child, as he suffers from Mental Retardict. He sees life with all naivety, for him everyone is a friend and every problem is a playground that he must play with a smile. Yoyo spends his days spreading kindness and doesn't care if someone insults him.

Centered around Ana, Hikmah invites viewers to surrender only to Allah and to be faithful in His path despite the trials. Behind all trials, there is definitely a lesson waiting. God gives trials to make humans stronger and closer to Him.