Focuses on a group of toddlers, most prominently Tommy, Chuckie, Phil, Lil, and Angelica, and their day-to-day lives, usually involving common life experiences that become adventures in the babies' imaginations. Adults in the series are almost always unaware of what the children are up to; however, this only provides more room for the babies to explore and discover their surroundings.

Joe Gennaro is a laid-off executive who can't find work, so he decides to stay at home and take care of the children while his wife goes to work as a temp secretary. Later, Joe takes a job as a chef at his brother's restaurant.