Chacaleria is a crime film about Antonia, a self-made entrepreneur who, after losing her livelihood to the COVID-19 pandemic, wants to secure her financial future by selling and distributing alcohol illegally using a drone during Panama's nationally mandated dry law. This becomes increasingly difficult when Ronny, a by the book cop, who is forced to be corrupt, catches Antonia in the act and blackmails her into robbing a bank.
Political tensions in Panama burst with the rumors of the rejection of the Herran-Hay Treaty, that'd grant the U.S.A. the rights to build the Canal. José Agustín Arango decides it's time to start a secret revolution for Independence, joining forces with prominent isthmian businessmen and politicians, and getting help from strong international figures like Theodore Roosevelt, William Nelson Cromwell and Philippe Bunau-Varilla in a "chess game" that some call "the Greatest Revolution of all time".