Yukimasa Yugami is a detective who chases after facts in cases. He will resort to illegal investigations and he uses his unique reasoning powers. His partner is rookie detective Torao Hanyu.

When Natsuki Aizawa was a child, she was kidnapped which left her traumatized. Natsuki grew up relying on her friend Kentaro Yuki. She now studies physics at a university. One day, she meets newly appointed professor Shuya Tatsumi. Afterwards, mysterious events continually happen around Natsuki Aizawa. Shuya is time traveller who travels between the future and the past.

Up till 20 years ago, together with his father and 3 other people, Homura Masayoshi was part of the legendary group of thieves that called themselves 「TAKE FIVE」. This group stole from the rich who had acquired their wealth through immoral means. Due to an incident, Masayoshi decided to retire from the group, and settled into his life as a professor of Psychology at a reputable university. One day, he runs into a mysterious homeless woman, who passes him a picture of a Leonardo Da Vinci's painting, which prompts him to re-enter the world of thievery and resurrect 「TAKE FIVE」. Sasahara Rui joined the Burglary Division in the footsteps of her father, who had died in an accident involving a burglary heist. She wows to take down 「TAKE FIVE」 and stop them from stealing again. What was the real reason for the disbanding of 「TAKE FIVE」 20 years ago? Who is the mysterious homeless woman and what is the significance of the Da Vinci picture she had given to Masayoshi? How did Rui's father really died?

Detective Ukyo Sugishita confronts crime on the basis of his own convictions. He has a partner that works for him in the Special Task Unit. For the first 7 seasons, Ukyo’s first partner is Kaoru Kameyama. He is a good-natured, hot-tempered, straightforward and somewhat scattered detective. Beginning in Season 8, Takeru Kanbe replaces Kameyama. Contrary to his predecessor, Takeru is a lanky, cool, conceited and confident detective. From Season 11 to Season 13, Ukyo’s partner is a young detective Toru Kai. Toru is a son of Deputy Director-General of The National Police Agency. But he became a detective by his own effort. And starting with Season 14, Ukyo’s current partner is Wataru Kaburagi, an elite bureaucrat who came to the Metropolitan Police Department on temporary assignment. As the first partner without any career of a police officer, he will face challenging cases together with Ukyo.

Mifuyu is a high school student. Her mom suffers from a severe illness, which causes Mifuyu to spend most of her time taking care of her and doing housework. She doesn't think about her future after high school. Mifuyu's mom dies, her dad brings his girlfriend to their house and kicks Mifuyu out. Mifuyu goes to the home where her mom's cousin lives, in a high-class residential area in Tokyo.

High school teacher Hara Takako is 32 and has no boyfriend. She is desperate and insecure. One day, a new teacher Ozu Kota, seven years Takako’s junior is assigned to her school. Takako takes a romantic interest in Kota and the two of them grow attracted to each other. But in truth, Kota has a fiancee. Seeing the disconsolate Takako, reignites the love of Kurosawa Akio, a senior teacher whom she once had an affair with. ~~ Based on manga series "Hakuba no Oujisama" by Yukizou Saku.

50-year-old Okita Makoto is a middle-aged man who is old-fashioned and prejudiced against certain people and behaviors. Because of his values, he is disliked by his son, who likes cute things, his fujoshi daughter, who likes BL, and his wife, who is a fan of male idols. After meeting a gay young man, Makoto begins to slowly change his way of thinking...

Saionji Hajime is the perfect butler and he works for a madame who is elegant. The madame is full of curiosity and has a pure personality. Hajime began to work for the madame before her husband died and they share a deep level of trust. One day, they face murder case. The madame holds doubts about the murder case. Hajime uses his great reasoning powers in an attempt to solve the mystery.