Samantha Stephens is a seemingly normal suburban housewife who also happens to be a genuine witch, with all the requisite magical powers. Her husband Darrin insists that Samantha keep her witchcraft under wraps, but situations invariably require her to indulge her powers while keeping her bothersome mother Endora at bay.

The Maverick boys - Bret, Bart, Beau and Brent - are a clan of well-dressed dandies, gamblers who'd much rather make their money playing cards than messing up their fine clothing with actual work. Sly and clever, none of the Mavericks are much for acts of derring do, but they can be courageous when the situation calls for it. Most often, however, they live by their wits and considerable charm.

While on a mission, American astronaut Captain Tony Nelson is forced to make an emergency landing that will forever change his life. On a deserted South Pacific island, Captain Nelson happens upon a bottle containing a beautiful two-thousand-year-old female genie named Jeannie. Rescuing her from the bottle nets Tony the requisite three wishes, and then some, when Jeannie pledges total devotion to her new "master".