Mel is a local politician from a political family. When a family scandal leaves her niece, Lennox, and nephew, Ryder, without their parents, Mel takes them in. She hires Joe to become the family's male nanny, or "manny," after a Ponzi scheme leaves him broke.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.

Dexter Morgan, a blood spatter pattern analyst for the Miami Metro Police also leads a secret life as a serial killer, hunting down criminals who have slipped through the cracks of justice.

The lives of staff in the womens' health clinic of a fictitious hospital in Philadelphia.

Maddie and Ben have been dating for nine years and they know each other inside and out. Maddie's younger sister, Mia, has been dating Casey for seven weeks. With a shared c'est la vie attitude, Mia and Casey announce they're getting married and having a baby. It's news that throws Maddie for a loop. Surprisingly, the girls' parents, who have recently adopted a carpe diem sort of philosophy, couldn't be more pleased.

A locally born and bred S.W.A.T. lieutenant is torn between loyalty to the streets and duty to his fellow officers when he's tasked to run a highly-trained unit that's the last stop for solving crimes in Los Angeles.

Having left behind Seattle Grace Hospital, renowned surgeon Addison Forbes Montgomery moves to Los Angeles for sunnier weather and happier possibilities. She reunites with her friends from medical school, joining them at their chic, co-op, Oceanside Wellness Center in Santa Monica.