Prime Evil's rival, Big Evil arrives at Hauntquarters and using his Specter Scepter overpowers and imprisons the villain. In order to save the Earth the Ghostbusters find themselves working alongside Prime Evil.

Lou Scheimer
Tracy the Gorilla / Anabone / Skelevision / Fuddy / Fib Face / Sir Trance-A-Lot

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Alan Oppenheimer
Merlin / Prime Evil / Fangster / Captain Long John Scarechrome / Airhead

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Pat Fraley
Jake Kong, Jr. / Ghost Buggy, Jr. / Scared Stiff

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Susan Blu
Belfry / Futura / Jessica Wray

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Linda Gary
Madam Why / Mysteria / Apparitia

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Erika Scheimer
Corky / Skelevator / Shock Clock

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Peter Cullen
Eddie Spenser, Jr. / Haunter / Brat-a-Rat / Floatzart / Big Evil / Corpulon

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Guest stars