Dr. Charles and Dr. Reese search for answers when a mother brings in her daughter claiming she is possessed. Dr. Rhodes and Dr. Bekker are tasked with finding a way to save a pair of conjoined twins. Dr. Halstead struggles to get Dr. Manning's attention. Maggie measures her options in the wake of her recent actions.

Nick Gehlfuss
Dr. Will Halstead

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Marlyne Barrett
Maggie Lockwood

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Yaya DaCosta
April Sexton

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S. Epatha Merkerson
Sharon Goodwin

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Torrey DeVitto
Dr. Natalie Manning

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Oliver Platt
Dr. Daniel Charles

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Rachel DiPillo
Dr. Sarah Reese

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Colin Donnell
Dr. Connor Rhodes

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Brian Tee
Dr. Ethan Choi

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Norma Kuhling
Dr. Ava Bekker

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Guest stars