After taking the lead on a surgery, Dr. Bekker feels the heat after something goes wrong. Dr. Manning and Dr. Charles are faced with a tough decision concerning the gender of a 9-year-old girl. April and Dr. Reese rush to find the son of a dying patient. Goodwin's godson is admitted to the hospital.

Nick Gehlfuss
Dr. Will Halstead

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Marlyne Barrett
Maggie Lockwood

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Yaya DaCosta
April Sexton

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S. Epatha Merkerson
Sharon Goodwin

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Torrey DeVitto
Dr. Natalie Manning

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Oliver Platt
Dr. Daniel Charles

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Rachel DiPillo
Dr. Sarah Reese

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Colin Donnell
Dr. Connor Rhodes

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Brian Tee
Dr. Ethan Choi

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Norma Kuhling
Dr. Ava Bekker

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Guest stars