After a shooting occurs during a block party, the staff is overrun with victims; Dr. Choi devises a new mass casualty plan; Dr. Manning struggles to stay focused when she realizes her son and nanny might have been at the scene.

Nick Gehlfuss
Dr. Will Halstead

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Marlyne Barrett
Maggie Lockwood

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Yaya DaCosta
April Sexton

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S. Epatha Merkerson
Sharon Goodwin

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Torrey DeVitto
Dr. Natalie Manning

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Oliver Platt
Dr. Daniel Charles

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Rachel DiPillo
Dr. Sarah Reese

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Colin Donnell
Dr. Connor Rhodes

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Brian Tee
Dr. Ethan Choi

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Norma Kuhling
Dr. Ava Bekker

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Guest stars