A case brings back memories for Alex, Jesse and Millicent as they fight to save a heart transplant patient when she sustains devastating injuries in a car crash.

Melissa George
Dr. Alex Panttiere

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Don Hany
Dr. Jessie Shane

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Shelley Conn
Dr. Millicent Patel

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Dave Annable
Dr. Pierce Harrison

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Maya Erskine
Nurse Ji-Sung

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Rudy Martinez
Marty

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Jamie Kennedy
Dr. Callahan

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JLouis Mills
Forester

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Joshua Leonard
Max

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D.L. Hughley
Dr. Hackett

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Caitlyn Larimore
Lynn

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Bryan Espino
Intern

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Issac Wolf
Intern

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Guest stars